Touchdown  PCR is initiated at very high annealing temperatures, which allow only perfectly matched primer-template DNA hybrids to form and support amplification. The annealing temperature is dropped in a stepwise fashion with each cycle of PCR. 

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#Id: 5794

#Unit 7. System Physiology – Animal

Tyrosine is first iodized to monoiodotyrosine and then to diiodotyrosine. Then, more and more of the iodotyrosine residues become coupled with one another

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#Id: 5795

#Unit 7. System Physiology – Animal

TLS Online TPP Program

#Id: 5796

#Unit 7. System Physiology – Animal

The major hormonal product of the coupling reaction is the molecule thyroxine (T4), which is formed when two molecules of DIT are joined together; the thyroxine then remains part of the thyroglobulin molecule.

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#Id: 5797

#Unit 7. System Physiology – Animal

Iodinated Tyrosines (MIT and DIT) are deiodinated by a microsomal iodotyrosine deiodinase, to recover iodine and bound tyrosines and recycle them for additional rounds of hormone synthesis.

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#Id: 5798

#Unit 7. System Physiology – Animal

The thyroid hormone receptor usually forms a heterodimer with retinoid X receptor (RXR) at specific thyroid hormone response elements on the DNA

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#Id: 5799

#Unit 7. System Physiology – Animal