To more accurately validate the predicted target genes of miRNAs and exactly determine the cleavage sites within the targets, an integrated strategy comprising RLM-RACE, Poly(A) Polymerase-Mediated (PPM)-RACE, and qRT-PCR was developed.

TLS Online TPP Program

#Id: 10367

#Unit 4. Cell Communication and Cell Signaling

Daudi tumor cells, which are unable to synthesize β 2-microglobulin. 

TLS Online TPP Program

#Id: 10368

#Unit 4. Cell Communication and Cell Signaling

Class II MHC glycoproteins expressed predominantly on pAPCs, where they primarily present exogenous antigenic peptides to CD4+ T cells.

TLS Online TPP Program

#Id: 10369

#Unit 4. Cell Communication and Cell Signaling

Class III MHC genes encode several different proteins, some with immune functions, include the complement components C4, C2, and factor B, TNF-α and Lymphotoxin-α [TNF- α]. 

TLS Online TPP Program

#Id: 10370

#Unit 4. Cell Communication and Cell Signaling

HLA-G

These are present on fetal cells at the maternal-fetal interface and are credited with inhibiting rejection by maternal CD8+ T cells by protecting the fetus from identification as foreign.

TLS Online TPP Program

#Id: 10371

#Unit 4. Cell Communication and Cell Signaling

A given MHC molecule can bind numerous different peptides, and some peptides can bind to several different MHC molecules. Because of this MHC molecule is often referred to as “promiscuous”.

TLS Online TPP Program

#Id: 10372

#Unit 4. Cell Communication and Cell Signaling