The run-on reaction is usually done in the presence of labeled nucleotides so the products will be labeled.

TLS Online TPP Program

#Id: 1333

#Unit 4. Cell Communication and Cell Signaling

Cholera toxin, secreted by Vibrio cholerae Catalyze a covalent modification of the Gαs protein Inhibit GAP activity.

TLS Online TPP Program

#Id: 1334

#Unit 4. Cell Communication and Cell Signaling

The pertussis toxin, produced by Bordetella pertussis Catalyze a covalent modification of the Gαi protein preventing GDP-GTP exchange.

TLS Online TPP Program

#Id: 1335

#Unit 4. Cell Communication and Cell Signaling

The bacterial toxins that cause cholera and pertussis are enzymes that catalyze transfer of the ADP ribose moiety.

TLS Online TPP Program

#Id: 1336

#Unit 4. Cell Communication and Cell Signaling

RTK ligands- NGF, PDGF, FGF, EGF

TLS Online TPP Program

#Id: 1337

#Unit 4. Cell Communication and Cell Signaling

All RTKs have a cytosolic domain with protein tyrosine kinase activity

TLS Online TPP Program

#Id: 1338

#Unit 4. Cell Communication and Cell Signaling

The EGFR specifically binds EGF in a lock-and-key type of mechanism.