In Size exclusion chromatography (SEC) Separation of different size molecules by exclusion chromatography. Large, excluded molecules are eluted first in the void.

TLS Online TPP Program

#Id: 1460

#Unit 4. Cell Communication and Cell Signaling

In cis interactions (intracellular or lateral interactions) monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane.

TLS Online TPP Program

#Id: 1461

#Unit 4. Cell Communication and Cell Signaling

CAMs fall into one of four major families: 

• Cadherins

• Immunoglobulin (Ig) superfamily

• Integrins

• Selectins

TLS Online TPP Program

#Id: 1462

#Unit 4. Cell Communication and Cell Signaling

The adhesiveness of cadherins depends on the presence of extracellular Ca2+.

TLS Online TPP Program

#Id: 1463

#Unit 4. Cell Communication and Cell Signaling

Two type of Cadherins:

1. Classical cadherin proteins

2. Nonclassical cadherin proteins

TLS Online TPP Program

#Id: 1464

#Unit 4. Cell Communication and Cell Signaling

Each classical cadherin molecule contains: 

A single transmembrane domain

A relatively short C-terminal cytosolic domain

Five extracellular “cadherin” domains (called EC1–EC5)

TLS Online TPP Program

#Id: 1465

#Unit 4. Cell Communication and Cell Signaling

Three classes of classical cadherins: 

E-cadherin -present on many types of epithelial cells

N-cadherin - present on nerve, muscle and lens cells

P-cadherin - present on cells in the placenta & epidermis