An ARS extends for -so bp and includes a consensus sequence (A} and additional elements (B1-B3).

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#Unit 2. Cellular Organization

when defective keratins are expressed in the basal cell layer of the epidermis, they produce a disorder called epidermolysis bullosa simplex

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#Unit 2. Cellular Organization

Vimentin, found in mesenchymal cells;

GFAP (glial fibrillary acidic protein), found in glial cells

Desmin, found in muscle cells

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In smooth muscle, desmin filaments link cytoplasmic dense bodies to the plasma membrane to ensure that cells resist overstretching.

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In skeletal muscle, 

The desmin filaments encircle the Z disk and are cross-linked to the plasma membrane. 

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#Unit 2. Cellular Organization

Type IV Ifs consist of the three related subunits

NF-L, NF-M, and NF-H that make up the neurofilaments found in the axons of neurons

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#Unit 2. Cellular Organization

Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) 

neurodegenerative disease 

associated with an accumulation and abnormal assembly

of neurofilaments in motor neuron cell bodies and in the axon