The key event in controlling replication is the behavior of the ORC complex at the origin.

Cdc6 protein is an unstable protein that is synthesized only in G1.

Cdc6 binds to ORC and allows MCM proteins.

Cdc6 binds to ORC and allows MCM proteins to bind.

Cdt1 facilitates MCM loading on origins

TLS Online TPP Program

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#Unit 2. Cellular Organization

The length of the myosin II neck domain determines the rate of movement.

TLS Online TPP Program

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#Unit 2. Cellular Organization

In the absence of ATP, the myosin head is firmly attached to the actin filament. 

TLS Online TPP Program

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#Unit 2. Cellular Organization

In the presence of ATP,  myosin head releases from the actin filament. 

TLS Online TPP Program

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#Unit 2. Cellular Organization

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

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#Unit 2. Cellular Organization

Smooth muscle cells and nonmuscle cells are regulated by:

Norepinephrine, angiotensin, endothelin, histamine

TLS Online TPP Program

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#Unit 2. Cellular Organization

Smooth muscle contraction is regulated by the cycling of myosin II between on and off states.