DNA polymerase III holoenzyme assembles in stages, generating an enzyme complex that synthesizes the DNA of both new strands.\
Binding to DNA changes the conformation of the site on B that binds to the clamp loader, and as a result it now has a high affinity for the core polymerase.
First the clamp loader uses hydrolysis ofATPtobindbeta subunits to a template primercomplex.
Binding to DNA changes the conformation of the site on B that binds to the clamp loader, and as a result it now has a high affinity for the core polymerase.
tau. dimer binds to the core polymerase, and provides a dimerization function thatbinds a second core polymerase (associated with another B2
#Unit 3. Fundamental Processes#Unit of replication and enzymes involved#Part B Pointers
