DNA ligase makes the bond that connects the 3 ' end of one Okazaki fragment to the 5 ' beginning of the next fragment.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

P53 turned on  p2I/WAF-I, which binds to and inhibits the CDK/cyclin complexes for GI arrest

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

P53 turned on sets of large intergenic noncoding RNAs to mediate transcription repression; and miRNAs.

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#Unit 4. Cell Communication and Cell Signaling

p2I -IincRNA, mediates the repressive properties of p53 by binding to specific chromatin complexes.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.

 

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

p53 amyloid aggregates,

No transport from cytoplasm to the nucleus

Escape proteasome degradation

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 demonstrated by biophysical techniques:

X-ray diffraction 

Fourier transform infrared spectroscopy (FTIR)