Deletion of the ter sites does not, however, prevent normal replication cycles from occurring, although it does affect segregation of the daughter chromosomes.

TLS Online TPP Program

#Id: 8167

#Unit 2. Cellular Organization

Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 4020

#Unit 2. Cellular Organization

Local genome alteration, termed kataegis involves activation-induced deaminase (AID)

Chromothripsis entire chromosomes or large parts thereof are shattered (thripsis in Greek means “shattering”) and stitched together again in what appears to be a random manner, leading to dozens or sometimes even hundreds of rearrangements.

TLS Online TPP Program

#Id: 3684

#Unit 2. Cellular Organization

The “introns early” hypothesis is the proposal that introns have always been an integral part of the gene.  Genes originated as interrupted structures, and those now without introns have lost them in the course of evolution.

TLS Online TPP Program

#Id: 4633

#Unit 13. Methods in Biology

3H thymidine uptake assays were the first to be used routinely to measure cell division in lymphocyte cultures

TLS Online TPP Program

#Id: 4764

#Unit 5. Developmental Biology

In the germ line, PAL-1 synthesis is prevented by the PUF-8 protein, which binds to the 3′ UTR of pal-1 mRNA and blocks its translation.