Mitochondria use different origin sequences to initiate replication of each DNA strand

Replication of the H strand is initiated in a D loop.

Replication of the L strand is initiated when its origin is exposed by the movement of the first replication fork.

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#Unit 3. Fundamental Processes

A genome in a bacterial cell has a single replication origin and thus constitutes a single replicon.

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#Unit 3. Fundamental Processes

Each haploid bacterium typically has a single chromosome, so this type of replication control is called single copy.

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#Unit 3. Fundamental Processes

The single circular chromosomes of Sulfolobus species have three origins and thus are composed of three replicons.

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#Unit 3. Fundamental Processes

Each eukaryotic chromosome contains a large number of replicons spaced unevenly throughout the chromosomes.

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The bacterial DnaA protein is the replication initiator; it binds sequence specifically to multiple sites (dnaA boxes) in oriC.

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Activity of the replication origin is controlled is DNA methylation