In BER,  DNA polymerase I initiates repair synthesis from the free 3’ hydroxyl at the nick, removing (with its 5’-3’ exonuclease activity) and replacing a portion of the damaged strand. 

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

A given MHC molecule can bind numerous different peptides, and some peptides can bind to several different MHC molecules. Because of this MHC molecule is often referred to as “promiscuous”.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

MHC-Peptide Interaction

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

One individual, however, expresses only a small number of these molecules—up to six different class I molecules and 12 or more different class II molecules.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

MHC molecules in mouse