Given step with the highest amount of free energy is a rate limiting step

TLS Online TPP Program

#Id: 7397

#Unit 5. Developmental Biology

Pipe synthesis is inhibited in dorsal follicle cells

TLS Online TPP Program

#Id: 7398

#Unit 5. Developmental Biology

Ventral follicle cells synthesize Pipe. Pipe signal sulfates ventral vitelline proteins

TLS Online TPP Program

#Id: 7399

#Unit 5. Developmental Biology

Sulfated vitelline membrane proteins bind Gastrulation-defective.

TLS Online TPP Program

#Id: 7400

#Unit 5. Developmental Biology

GD cleaves Snake to its active form and forms a complex with Snake and uncleaved Easter proteins.

Easter protein is cleaved into its

active form.

TLS Online TPP Program

#Id: 7401

#Unit 5. Developmental Biology

Cleaved Easter binds to and cleaves Spätzle; activated Spätzle binds to Toll receptor protein

TLS Online TPP Program

#Id: 7402

#Unit 5. Developmental Biology

Toll activation activates Tube and Pelle, which phosphorylate the Cactus protein. Cactus is degraded, releasing it from Dorsal.