In addition to proteins involved in NER, a variant form of XP called XP-V is caused by a defect in the translesion DNA polymerase, Pol h. The gene encoding Pol h is sometimes called XPV. Individuals with XP-V have a milder form of XP.

TLS Online TPP Program

#Id: 10488

#Unit 4. Cell Communication and Cell Signaling

Most tumor cells,express MHC class I molecules on their surface, cytotoxic T cells can directly recognize tumor cells expressing neo-antigens.

TLS Online TPP Program

#Id: 10489

#Unit 4. Cell Communication and Cell Signaling

Cytotoxic T cells release granules containing the proteins perforin and granzyme-B

TLS Online TPP Program

#Id: 10490

#Unit 4. Cell Communication and Cell Signaling

perforins punch holes in the endocytic vesicle membrane, allowing granzymes to enter the cytoplasm

TLS Online TPP Program

#Id: 10491

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10492

#Unit 4. Cell Communication and Cell Signaling

Granzymes are serine proteases and cleave and activate

apoptotic molecules within the target cells, causing programmed cell death.

TLS Online TPP Program

#Id: 10493

#Unit 4. Cell Communication and Cell Signaling

Some Cytotoxic T cells express on their surface FasL, a natural ligand molecule related to TNF