The two chromophores in E. coli photolyase (Mr 54,000), N5 N10-methenyltetrahydrofolylpolyglutamate (MTHF polyGlu) and FADH , perform complementary functions.

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#Id: 9998

#Unit 4. Cell Communication and Cell Signaling

Wnt/calcium pathway leads to the release of calcium stored within cells, and calcium acts as an important secondary messenger to modulate the function of many downstream targets.

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#Id: 9999

#Unit 4. Cell Communication and Cell Signaling

Increased Ca2+ levels activates Ca2+-dependent signaling molecules such as:

Protein kinase C, Ca2+/calmodulin-dependent protein kinase (CamKII), Calcineurin phosphatase

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#Unit 4. Cell Communication and Cell Signaling

Calcineurin phosphatase, dephosphorylates and activates the transcription factor, Nuclear Factor Associated with T cells (NFAT).

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#Unit 4. Cell Communication and Cell Signaling

Vertebrates have three homologues of the Drosophila hedgehog gene: sonic hedgehog (shh), desert hedgehog

(dhh), and indian hedgehog (ihh)

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#Id: 10002

#Unit 4. Cell Communication and Cell Signaling

Desert hedgehog protein is found in the Sertoli cells of the testes

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#Id: 10003

#Unit 4. Cell Communication and Cell Signaling

Mice homozygous for a null allele of dhh exhibit defective spermatogenesis