Nurturing Life Sciences
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#Unit 3. Fundamental Processes
Replication inserts the normal (nonmodified) bases into the daughter strands. This generates hemimethylated DNA, in which one strand is methylated and one strand is unmethylated.
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Initiation may require full methylation of the Dam target sites in the origin, or it may be inhibited by hemimethylation of these sites.
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Eukaryotic cells have many DNA polymerases. The replication enzymes operate with high fidelity. Except for the β enzyme, the repair enzymes all have low fidelity.