Genes are not uniformly distributed in the genome.

Regions longer than 500 kb where there are no ORFs called as deserts

The most gene-rich chromosomes have 10% of their sequences as deserts. So overall, 20% of the human genome consists of deserts that have no protein coding genes.

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#Unit 3. Fundamental Processes

Once replication has started, it continues until the entire genome has been duplicated.

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#Unit 3. Fundamental Processes

The unit of DNA in which an individual act of replication occurs is called the replicon

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#Unit 3. Fundamental Processes

“Replicon” is usually applied to eukaryotic chromosomes to describe a unit of replication that contains an origin; trans-acting regulator protein

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#Unit 3. Fundamental Processes

A replicon has origin at which replication is initiated. It may also have a terminus at which replication stops.

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#Unit 3. Fundamental Processes

A genome in a bacterial cell has a single replication origin and thus constitutes a single replicon.

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#Unit 3. Fundamental Processes

Each haploid bacterium typically has a single chromosome, so this type of replication control is called single copy.