The H2A variants are the largest and most diverse family of core histone variants.

TLS Online TPP Program

#Id: 5205

#Unit 7. System Physiology – Animal

Anticlotting mechanisms  The tendency of blood to clot is balanced in vivo by reactions that prevent clotting inside the blood vessels, break down any clots that 

do form, or both.

TLS Online TPP Program

#Id: 5206

#Unit 7. System Physiology – Animal

Antithrombin III is a circulating protease inhibitor that binds to serine proteases in the coagulation system, blocking their activity as clotting factors.

TLS Online TPP Program

#Id: 5207

#Unit 7. System Physiology – Animal

Antithrombin III is a circulating protease inhibitor that binds to serine proteases in the coagulation system, blocking their activity as clotting factors.

TLS Online TPP Program

#Id: 5208

#Unit 7. System Physiology – Animal

The endothelium of the blood vessels also plays an active role in preventing the extension of clots. 

TLS Online TPP Program

#Id: 5209

#Unit 7. System Physiology – Animal

All endothelial cells except those in the cerebral microcirculation produce thrombomodulin,  a thrombin-binding protein, on their surfaces.

TLS Online TPP Program

#Id: 5210

#Unit 7. System Physiology – Animal

In circulating blood, thrombin is a procoagulant that activates factors V and VIII, but when it binds to thrombomodulin, it becomes an anticoagulant in that the thrombomodulin–thrombin complex activates protein C.