TLS Online TPP Program

#Id: 8200

#Unit 2. Cellular Organization

For optimal activity, of acid hydrolases they need to be: Activated by proteolytic cleavage Requires an acid environment.

TLS Online TPP Program

#Id: 8201

#Unit 2. Cellular Organization

Lysosome an interior pH of about 4.5–5.0

TLS Online TPP Program

#Id: 8202

#Unit 2. Cellular Organization

Most of the lysosome membrane proteins, are highly glycosylated, which helps to protect them from the lysosome proteases

TLS Online TPP Program

#Id: 8203

#Unit 2. Cellular Organization

An H+ ATPase in the membrane pumps H+ into the lysosome, maintaining its lumen at an acidic pH.

TLS Online TPP Program

#Id: 8204

#Unit 2. Cellular Organization

Lysosome H+ pump are V-type ATPases and has a similar architecture to the F-type ATPases

TLS Online TPP Program

#Id: 8205

#Unit 2. Cellular Organization

Membranes of late endosomes and lysosomes contain V-class proton pumps that act in concert with Cl- channels to acidify the vesicle lumen.