(CFSE) or carboxyfluorescein diacetate succinimidyl ester (CFDASE) is nontoxic to cells hence retained till many cycles

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#Id: 1229

#Unit 7. System Physiology – Animal

PTH actions on the kidney:

1.  Inhibits phosphate reabsorption

2.  Stimulates Ca2+ reabsorption

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#Id: 1230

#Unit 7. System Physiology – Animal

PTH stimulates renal 1α-hydroxylase.

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#Id: 1231

#Unit 7. System Physiology – Animal

1α-hydroxylase, converts 25-hydroxycholecalciferol to the active form, 1,25-dihydroxycholecalciferol.

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#Id: 1232

#Unit 7. System Physiology – Animal

In the intestine,

1,25-dihydroxycholecalciferol induces the synthesis of calbindin D-28 K which promotes Ca2+ absorption.

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#Id: 1233

#Unit 7. System Physiology – Animal

1,25-dihydroxycholecalciferol stimulates the reabsorption of calcium & phophate ions from kidney.

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#Id: 1234

#Unit 7. System Physiology – Animal

In bone, 

1,25-dihydroxycholecalciferol acts synergistically with PTH to stimulate osteoclast activity and bone resorption.