TLS Online TPP Program

#Id: 5539

#Unit 7. System Physiology – Animal

In the thick ascending loop,  Luminal membrane contains a three-ion cotransporter  known as Na+-K+-2Cl- cotransporter

TLS Online TPP Program

#Id: 5540

#Unit 7. System Physiology – Animal

Thick ascending limb is called the diluting segment because NaCl is reabsorbed but water is not reabsorbed along with it 

TLS Online TPP Program

#Id: 5541

#Unit 7. System Physiology – Animal

The Cl – moves into the interstitium via ClC-Kb channels & Barttin, a protein in the cell membrane, is essential for normal ClC-Kb

function

TLS Online TPP Program

#Id: 5542

#Unit 7. System Physiology – Animal

The thick ascending limb of the loop of Henle is the site of action of the powerful “loop” diuretics such as

Furosemide

Ethacrynic acid

Bumetanide 

TLS Online TPP Program

#Id: 5543

#Unit 7. System Physiology – Animal

At physiologic pH, the loop diuretics are anions that attach to the Cl−-binding site of the Na+-K+-2Cl− cotransporter.

TLS Online TPP Program

#Id: 5544

#Unit 7. System Physiology – Animal

The thick ascending limb has a sodium-hydrogen counter-transport