The second parity rule applies more closely to introns than to exons.

TLS Online TPP Program

#Id: 794

#Unit 3. Fundamental Processes

Rho activity is impeded when ribosomes are translating an mRNA.

TLS Online TPP Program

#Id: 795

#Unit 3. Fundamental Processes

The action of rho factor may create link between transcription and translation when a rho-dependent terminator lies soon after a nonsense mutation.

TLS Online TPP Program

#Id: 796

#Unit 3. Fundamental Processes

Nonsense mutation in one gene of a transcription unit was found to prevent the expression of subsequent genes in the unit even though both genes had their own ribosome binding sites, an effect called polarity.

TLS Online TPP Program

#Id: 797

#Unit 3. Fundamental Processes

There are proteins so-called nut sites in the leader regions of both the 16S and 23S rRNA transcripts, forming antitermination complexes that inhibit the action of rho.

TLS Online TPP Program

#Id: 798

#Unit 3. Fundamental Processes

rho mutants are usually leaky

TLS Online TPP Program

#Id: 799

#Unit 3. Fundamental Processes

Mutations in the rpoB gene can reduce termination at a rho-dependent site.  Mutations in rpoB can restore the ability to terminate transcription at rho-dependent sites in rho mutant bacteria.