Glial cells 

Play important role in communication within the CNS in partnership with neurons & continue to undergo cell division in adulthood.Have the ability to proliferate after brain injury.

TLS Online TPP Program

#Id: 9474

#Unit 4. Cell Communication and Cell Signaling

SHP1 

Binding of an SH2 domain to a phosphotyrosine in the activated receptor unmasks its phosphatase catalytic site

TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.

TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 

expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods

TLS Online TPP Program

#Id: 9477

#Unit 4. Cell Communication and Cell Signaling

All SOCS proteins contains:

SH2 domain

SOCS box

TLS Online TPP Program

#Id: 9478

#Unit 4. Cell Communication and Cell Signaling

SOCS box, 

Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome

TLS Online TPP Program

#Id: 9479

#Unit 4. Cell Communication and Cell Signaling

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity