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TLS Online TPP Program

#Id: 5455

The spatial distribution of ion channels along the axon plays a key role in the initiation and regulation of the action potential




#Unit 7. System Physiology – Animal #Nervous system, Neurons, action potential #Part B Pointers
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TLS Online TPP Program

#Id: 1575

#Unit 4. Cell Communication and Cell Signaling

Binding of Axin to the phosphorylated LRP protein and to Dishevelled disrupts the Axin–APC–CK1–GSK3–β-catenin complex. 
TLS Online TPP Program

#Id: 1576

#Unit 4. Cell Communication and Cell Signaling

Unphosphorylated β-catenin translocates to the nucleus.
TLS Online TPP Program

#Id: 1577

#Unit 4. Cell Communication and Cell Signaling

β-catenin binds to TCF to displace the Gro repressor and recruits co-activator proteins Pygo, LGS, to activate target gene expression.
TLS Online TPP Program

#Id: 1578

#Unit 4. Cell Communication and Cell Signaling

Active Wnt signaling leads to the secretion of Notum.
 
TLS Online TPP Program

#Id: 1579

#Unit 4. Cell Communication and Cell Signaling

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.
TLS Online TPP Program

#Id: 1580

#Unit 4. Cell Communication and Cell Signaling

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.