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Principle of one-way conduction at chemical synapses 
always transmit the signals in one direction i.e., from the neuron that secretes the neurotransmitter called the presynaptic neuron, to the neuron on which the transmitter acts, called the postsynaptic neuron


#Unit 7. System Physiology – Animal #Nervous system, Neurons, action potential #Part B Pointers
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#Unit 7. System Physiology – Animal

Tyrosine is transported into catecholamine-secreting neurons via a Na+ - dependent carrier



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#Unit 7. System Physiology – Animal

Rate-limiting step in synthesis of catecholamines:  Tyrosine is converted to dihydroxy-phenylalanine (DOPA) by tyrosine hydroxylase

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#Unit 7. System Physiology – Animal

DOPA is converted to dopamine in the cytoplasm of the cells by DOPA decarboxylase (amino acid decarboxylase)



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#Unit 7. System Physiology – Animal

DOPA is converted to dopamine in the cytoplasm of the cells by DOPA decarboxylase (amino acid decarboxylase)

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#Unit 7. System Physiology – Animal

Dopamine is converted to norepinephrine by dopamine β -hydroxylase





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#Unit 7. System Physiology – Animal

Norepinephrine is the only small-molecule transmitter that is synthesized in synaptic vesicles


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