At physiologic pH, the loop diuretics are anions that attach to the Cl−-binding site of the Na+-K+-2Cl− cotransporter.

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#Id: 5789

#Unit 7. System Physiology – Animal

Iodide is transported out of the thyroid cells across the apical membrane into the follicle by a chloride-iodide ion counter- transporter molecule called pendrin.

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#Unit 7. System Physiology – Animal

Thyroglobulin is a glycoprotein contains 123 tyrosine residues, but only 4–8 of these are normally incorporated into thyroid hormones.

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#Id: 5791

#Unit 7. System Physiology – Animal

Oxidation of iodine is mediated by thyroid peroxidase, a membrane-bound enzyme found in the thyrocyte apical membrane.

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#Unit 7. System Physiology – Animal

When the peroxidase system is blocked or when it is hereditarily absent from the cells, the rate of formation of thyroid hormones falls to zero

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#Id: 5793

#Unit 7. System Physiology – Animal

“Organification” of Thyroglobulin- Iodination of tyrosine and formation of the thyroid hormones

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#Unit 7. System Physiology – Animal

Tyrosine is first iodized to monoiodotyrosine and then to diiodotyrosine. Then, more and more of the iodotyrosine residues become coupled with one another