At physiologic pH, the loop diuretics are anions that attach to the Cl−-binding site of the Na+-K+-2Cl− cotransporter.

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#Id: 7428

#Unit 5. Developmental Biology

Early on during aggregation, gene expression requires the activity of cAMP-dependent protein kinase.

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#Id: 7429

#Unit 5. Developmental Biology

High PSF to food ratio is upregulate the translation of the PKA catalytic subunit PKA-C.

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#Id: 7430

#Unit 5. Developmental Biology

A second glycoprotein secreted during starvation is CMF (conditioned medium factor)

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#Id: 7431

#Unit 5. Developmental Biology

CMF stimulates gene expression in parallel with PSF, and both signals potentiate cAMP signalling by inducing genes involved in cAMP synthesis and detection

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#Id: 7432

#Unit 5. Developmental Biology

Newly activated genes are:

Adenylate cyclase A (ACA)

PKA

cAMP receptors (cARs)

Extracellular cAMP phosphodiesterase PdsA

An intracellular cAMP phosphodiesterase RegA

TLS Online TPP Program

#Id: 7433

#Unit 5. Developmental Biology

Once all proteins are functioning, a few starving cells start to emit cAMP pulses.