Vibration of the organ of Corti causes bending of stereocilia on the hair cells by a shearing force as the cilia push against the tectorial membrane

TLS Online TPP Program

#Id: 814

#Unit 3. Fundamental Processes

Mechanism: How Polymerase Find Promoter Sequences

TLS Online TPP Program

#Id: 815

#Unit 3. Fundamental Processes

Sigma inhibits non specific binding of holoenzyme so fourth slides rapidly over non promoters sequences but binding strongly to promoters

TLS Online TPP Program

#Id: 816

#Unit 3. Fundamental Processes

Sigma factor has four binding regions over DNA. 

TLS Online TPP Program

#Id: 817

#Unit 3. Fundamental Processes

Region 2.3, 2.4, and 4.2 contact bases in the -10 and -35 elements, respectively; 

sigma factor region 1.2 contacts the promoter region just downstream from the -10 element, and region 3.0 contacts the promoter region just upstream from the -10 element.

 

TLS Online TPP Program

#Id: 818

#Unit 3. Fundamental Processes

Sigma factor Region 2.3 is responsible for melting the DNA at -10 element.

TLS Online TPP Program

#Id: 1841

#Unit 3. Fundamental Processes