Central diabetes insipidus – Failure to Produce ADH Nephrogenic diabetes insipidus - Inability of the Kidneys to Respond to ADH

TLS Online TPP Program

#Id: 623

#Unit 2. Cellular Organization

Dual hairpin formation take place due to ribosome fall from UGA

TLS Online TPP Program

#Id: 624

#Unit 2. Cellular Organization

Dual hairpin formation (Region 3-4 forms hairpin then second hairpin is formed between Region 1-2) release RNA-DNA hybrid and RNA Polymerase causes seizing transcription of trp operon at high trp concentration.

TLS Online TPP Program

#Id: 625

#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) region 1 is translated atleast till codon 10 and 11 in case of Low trp concentration because ribosomes get stalled due to low availability of charged tRNA-trp

TLS Online TPP Program

#Id: 626

#Unit 2. Cellular Organization

In case of Low trp concentration, RNA polymerase continues to EDCBA genes where new ribosome get attached to AUG of polycistronic genes

TLS Online TPP Program

#Id: 627

#Unit 2. Cellular Organization

RNA Polymerase don’t get dissociated with one hairpin which is 2:3 

TLS Online TPP Program

#Id: 628

#Unit 2. Cellular Organization

Transcription is initiated at the beginning of the 162 nucleotide mRNA leader encoded by a DNA region called trpL.