#Id: 7089
#Unit 3. Fundamental Processes
IF1 prevents tRNAs from binding to the portion of the small subunit that will become part of the A-site.
†IF2 is a GTPase that interacts with three key components of the initiation machinery: the small subunit, IF1, and the charged initiator tRNA (fMet-tRNAi f-Met). By interacting with these components, IF2 facilitates the association of fMet-tRNAi f-Met with the small subunit and prevents other charged tRNAs from associating with the small subunit.
† IF3 binds to the small subunit and blocks it from reassociating with a large subunit. Because initiation requires a free small subunit, the binding of IF3 is critical for a new cycle of translation.
