Addison disease (primary adrenocortical insufficiency) caused by autoimmune destruction of all zones of the adrenal cortex.

TLS Online TPP Program

#Id: 8577

#Unit 2. Cellular Organization

In skeletal muscle, 

The desmin filaments encircle the Z disk and are cross-linked to the plasma membrane. 

TLS Online TPP Program

#Id: 576

#Unit 2. Cellular Organization

The DNA-binding domain occupies residues 1–59. It contains two a-helices separated by a turn. This is a common DNA-binding motif known as the HTH (helix-turn-helix); the two a-helices fit into the major groove of DNA

TLS Online TPP Program

#Id: 9752

#Unit 6. System Physiology – Plant

Phloem feeders activate the salicylic acid signaling pathway, as similar to pathogen infections.

TLS Online TPP Program

#Id: 808

#Unit 3. Fundamental Processes

A promoter is defined by the presence of short consensus sequences at specific locations.

TLS Online TPP Program

#Id: 6504

#Unit 3. Fundamental Processes

Once bound to Pol II, Ptefb phosphorylates the serine residue at position 2 of the CTD repeats. That phosphorylation event correlates with elongation. In addition, P-TEFb phosphorylates and thereby activates another protein, called SPT5, itself an elongation factor. Finally, TAT-SF1, yet another elongation factor, is recruited by P-TEFb. Thus, P-TEFb stimulates elongation in three separate ways.