TLS Online TPP Program

#Id: 5891


DNA binds in a large cleft composed of three domains. The “palm” domain has important conserved sequence motifs that provide the catalytic active site. The “fingers” are involved in positioning the template correctly at the active site. The “thumb” binds the DNA as it exits the enzyme, and is important in processivity.

#Unit 3. Fundamental Processes #Mechanism of DNA synthesis in Prokaryotes #Part B Pointers