The holoenzyme is a complex of 900 kD that contains 10 different proteins organized into four types of subcomplex

1. Atleast two copies of the catalytic core.

2. two copies of the dimerizing subunit, t, which link the two catalytic cores together.

3. There are two copies of the clamp

4. The g complex is a group of seven proteins, encoded by five genes, that comprise the clamp loader

TLS Online TPP Program

#Id: 6893

#Unit 3. Fundamental Processes

There are two de novo methyltransferases (Dnmt3A and Dnmt3B) in the mouse; they have different target sites, and both are essential for development.

TLS Online TPP Program

#Id: 5286

#Unit 7. System Physiology – Animal

When the cholinergic vagal fibers to nodal tissue are stimulated, the membrane becomes hyperpolarized and the slope of the prepotentials is decreased

TLS Online TPP Program

#Id: 5487

#Unit 10. Ecological Principles

Age at first reproduction

Earlier age →  Later age 

Clutch size

Large clutch size → small clutch size

Small size →  Large size

Trade off

TLS Online TPP Program

#Id: 1934

#Unit 4. Cell Communication and Cell Signaling

C8 is made up of two peptide chains: C8β and C8αϒ. 

Binding of C8β to the C5b67 complex induces a conformational change in the C8 dimer such that the hydrophobic domain of C8αϒ can insert into the interior of the phospholipid membrane. 

TLS Online TPP Program

#Id: 3035

#Unit 3. Fundamental Processes

The clamp associated with the core on the lagging strand dissociates at the end of each Okazaki fragment and reassembles for the next fragment.