TLS Online TPP Program

#Id: 10429

#Unit 4. Cell Communication and Cell Signaling

Acute myeloid leukemias

characterized by DNA hypomethylation, due to inactivating mutations in an enzyme that catalyzes the methylation of CpG dinucleotides.

TLS Online TPP Program

#Id: 10430

#Unit 4. Cell Communication and Cell Signaling

SWI/SNF normally plays a role in repressing the E2F genes, inhibiting progression through the cell cycle.

TLS Online TPP Program

#Id: 10431

#Unit 4. Cell Communication and Cell Signaling

SNF5 protein is a core member of SWI/SNF complex. In humans, inactivating somatic SNF5 mutations cause rhabdoid tumors.

TLS Online TPP Program

#Id: 10432

#Unit 4. Cell Communication and Cell Signaling

Carcinogens are mutagens, they act by altering one or more nucleotides in DNA.

TLS Online TPP Program

#Id: 10433

#Unit 4. Cell Communication and Cell Signaling

Carcinogens can be classified into two categories: 

1. Direct-acting carcinogens

2. Indirect-acting carcinogens

TLS Online TPP Program

#Id: 10434

#Unit 4. Cell Communication and Cell Signaling

Direct-acting carcinogens

highly reactive compounds that can react with and modify nucleotide bases in DNA, to distort the normal pattern of base pairing.