Orc2-5 binds strongly; Orc6 binds weakly to ARS and has a nuclear localization signal that must be activated by the cyclin/ CDK kinase during the G1 to S transition.

TLS Online TPP Program

#Id: 6141

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6142

#Unit 3. Fundamental Processes

transcription-coupled repair (TC-NER) TFIIH, itself a large complex, which includes the products of two XP genes, XPB and XPD. 

TLS Online TPP Program

#Id: 6143

#Unit 3. Fundamental Processes

Cleavages are made on either side of the lesion by endonucleases encoded by the XPG and XPF genes. XPG is related to an endonuclease called FEN1 that cleaves DNA during the base excision repair pathway

TLS Online TPP Program

#Id: 6144

#Unit 3. Fundamental Processes

Finally, the single-stranded stretch including the damaged bases can then be replaced by new synthesis, and the final remaining nick is ligated by a complex of ligase III and XRCC1.

TLS Online TPP Program

#Id: 6145

#Unit 3. Fundamental Processes

Cockayne syndrome can be caused by mutations in either of two genes (CSA and CSB), both of whose products appear to be part of or bound to TFIIH, and can also be caused by specific mutations in XPB or XPD.

TLS Online TPP Program

#Id: 6146

#Unit 3. Fundamental Processes