Hence Cdc6 and Cdt1 are the key licensing factors and helicase loading proteins.

TLS Online TPP Program

#Id: 9906

#Unit 4. Cell Communication and Cell Signaling

Inflammation

Tissue response to infection or damage which serves to eliminate

Classic signs of acute inflammation are heat (calore), pain (dolore), redness (rubor), swelling (tumor), and loss of function (functio laesa).

TLS Online TPP Program

#Id: 9907

#Unit 4. Cell Communication and Cell Signaling

Inflammatory response

The response includes both localized and systemic effects, consisting of altered patterns of blood flow, an influx of phagocytic and other immune cells, removal of foreign antigens, and healing of the damaged tissue.

TLS Online TPP Program

#Id: 9908

#Unit 4. Cell Communication and Cell Signaling

Inflammatory response

TLS Online TPP Program

#Id: 9909

#Unit 4. Cell Communication and Cell Signaling

Inflammasomes

Multiprotein complex that promotes inflammation by processing inactive precursor forms of pro-inflammatory cytokines such as IL-1 and IL-18.

Proinflammatory cytokines IL-1β, TNF, and IL-6. 

TLS Online TPP Program

#Id: 9910

#Unit 4. Cell Communication and Cell Signaling

Inflammatory response

Inflammation may be acute (short-term effects)—for example, in response to local tissue damage.

it may be chronic (long term), contributing to conditions such as arthritis, inflammatory bowel disease, cardiovascular disease, and Type 2 diabetes.

TLS Online TPP Program

#Id: 9911

#Unit 4. Cell Communication and Cell Signaling

Arachidonic acid and some eicosanoid derivatives