TLS Online TPP Program

#Id: 5210

#Unit 7. System Physiology – Animal

In circulating blood, thrombin is a procoagulant that activates factors V and VIII, but when it binds to thrombomodulin, it becomes an anticoagulant in that the thrombomodulin–thrombin complex activates protein C.

TLS Online TPP Program

#Id: 5211

#Unit 7. System Physiology – Animal

Activated protein C (APC), along with its cofactor protein S, inactivates factors V and VIII and inactivates an inhibitor of tissue plasminogen activator, increasing the formation of plasmin.

TLS Online TPP Program

#Id: 5212

#Unit 7. System Physiology – Animal

Plasmin (fibrinolysin) is the active component of the plasminogen (fibrinolytic) system. 

TLS Online TPP Program

#Id: 5213

#Unit 7. System Physiology – Animal

Plasmin lyses fibrin and fibrinogen,  with the production of fibrinogen degradation products (FDP)  that inhibit thrombin. 

TLS Online TPP Program

#Id: 5214

#Unit 7. System Physiology – Animal

Plasmin is formed from its inactive precursor, plasminogen, by the action of thrombin and tissue-type plasminogen activator (t-PA).

TLS Online TPP Program

#Id: 5215

#Unit 7. System Physiology – Animal

Plasminogen is converted to active plasmin when t-PA hydrolyzes the bond between Arg 560 and Val 561. plasmin also activated by urokinase-type plasminogen activator (u-PA).