Mutations in MutS/L components can lead to hereditary nonpolyposis colorectal cancer (HNPCC). A characteristic feature of HNPCC is microsatellite instability, in which the lengths (numbers of repeats) of microsatellite sequences change rapidly in the tumor cells due to the loss of the mismatch repair system to correct replication slippage in these sequences.

TLS Online TPP Program

#Id: 9355

#Unit 4. Cell Communication and Cell Signaling

Most cells lack RIII, TGF-β binds directly to the RII

dimer, but Active RII kinase activity is not sufficient to generate an intracellular signal

TLS Online TPP Program

#Id: 3653

#Unit 3. Fundamental Processes

Some microorganisms that lack AsnRS use a similar transamidation pathway for the synthesis of Asn–tRNAAsn from Asp–tRNAAsn.

TLS Online TPP Program

#Id: 5998

#Unit 3. Fundamental Processes

An ARS element consists of an A-T–rich region that contains discrete sites in which mutations affect origin function.

TLS Online TPP Program

#Id: 6031

#Unit 3. Fundamental Processes

In mammalian systems where the DNA polymerase does not have a 5’–3’ exonuclease activity, Okazaki fragments are connected by a two-step process. 

TLS Online TPP Program

#Id: 1220

#Unit 7. System Physiology – Animal

When extracellular Ca2+ is decreased decreased Ca2+ binding to the receptor stimulates PTH secretion