In global genome repair (GG-NER), the XPC protein detects the damage and initiates the repair pathway. XPC can recognize damage anywhere in the genome. In mammals, XPC is a component of a lesion-sensing complex that also includes the proteins HR23B and centrin2.

TLS Online TPP Program

#Id: 9660

#Unit 4. Cell Communication and Cell Signaling

Many RTKs and cytokine receptors specifically activate the γ isoform (PLCγ), which contains an SH2 domain.

TLS Online TPP Program

#Id: 6023

#Unit 3. Fundamental Processes

DNA Pol a/ primase and DNA Pol d (which primarily act on the lagging strand) are only recruited after DNA unwinding.

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#Id: 10015

#Unit 4. Cell Communication and Cell Signaling

A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

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#Id: 5174

#Unit 7. System Physiology – Animal

The normal total circulating blood volume is about 8% of the body weight (5600 mL in a 70-kg man).  About 55% of this volume is plasma (3500 mL in a 70-kg man).

TLS Online TPP Program

#Id: 8503

#Unit 1. Molecules and their Interaction Relevant to Biology

At the highest level of classification, there are four type of secondary structures

All a

All b

a+b

a/b