Cleavages are made on either side of the lesion by endonucleases encoded by the XPG and XPF genes. XPG is related to an endonuclease called FEN1 that cleaves DNA during the base excision repair pathway

TLS Online TPP Program

#Id: 9980

#Unit 4. Cell Communication and Cell Signaling

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.

TLS Online TPP Program

#Id: 9981

#Unit 4. Cell Communication and Cell Signaling

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.

TLS Online TPP Program

#Id: 9982

#Unit 4. Cell Communication and Cell Signaling

Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.

TLS Online TPP Program

#Id: 9983

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9984

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9985

#Unit 4. Cell Communication and Cell Signaling

Antagonists of Wnt:

Secreted frizzled-related protein (Sfrp)

Wnt inhibitory factor (Wif)

Dickkopf (Dkk) family