Nurturing Life Sciences
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#Id: 2379
#Unit 3. Fundamental Processes
Prp8, a large scaffold protein that directly contacts both the 5’ and 3’ splice sites within the spliceosome.
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Prp5 is critical for U2 binding
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Brr2 facilitates U1 and U4 release
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Prp2 is responsible for the activation of the spliceosome Prp22 helps the release of the mature mRNA from the spliceosome
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Prp22 helps the release of the mature mRNA from the spliceosome, makes splicing irreversible.
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More than 90% of the genes expressed in mammals are alternatively spliced