Third generation adenoviral Vectors also known as helper dependent adenovirus as they lack all the coding sequences and require helper virus which carries all the coding sequences needed for successful infection like viral DNA replication, viral assembly and infection of new cells etc.

TLS Online TPP Program

#Id: 4771

#Unit 5. Developmental Biology

POP-1 activates the TBX-35 gene.

TLS Online TPP Program

#Id: 4772

#Unit 5. Developmental Biology

The TBX-35 transcription factor activates mesodermal genes in the MS cell, including pha-4 in the pharynx and hlh-1 in muscles.

TLS Online TPP Program

#Id: 4773

#Unit 5. Developmental Biology

TBX-35 inhibits pal-1 gene expression, preventing the MS cell from acquiring the C-blastomere fates.

TLS Online TPP Program

#Id: 4774

#Unit 5. Developmental Biology

At the 4-cell stage, the EMS cell requires a signal from its neighbor (and sister cell), the P2 blastomere.

TLS Online TPP Program

#Id: 4775

#Unit 5. Developmental Biology

The P2 cell produces the MOM-2 protein, a C. elegans Wnt protein.

TLS Online TPP Program

#Id: 4776

#Unit 5. Developmental Biology

MOM-2 is received in the EMS cell by the MOM-5 protein, a C. elegans protein Frizzled.