The genomes of all retroviruses contain the three genes gag, pol and env.

TLS Online TPP Program

#Id: 1684

#Unit 4. Cell Communication and Cell Signaling

This recombinational event is catalyzed by a set of enzymes, many of which are also involved in nonhomologous end joining (NHEJ) DNA repair functions that occur in all cells.

TLS Online TPP Program

#Id: 1685

#Unit 4. Cell Communication and Cell Signaling

Only three of the proteins implicated in V(D)J recombination are unique to lymphocytes: RAG1, RAG2, and Terminal deoxynucleotidyl Transferase (TdT)

TLS Online TPP Program

#Id: 1686

#Unit 4. Cell Communication and Cell Signaling

Recombination between the D and a JH gene segment occur during pre pro-B cell to the early pro-B-cell stage.

TLS Online TPP Program

#Id: 1687

#Unit 4. Cell Communication and Cell Signaling

Recombination between the VH and D-JH segments follows during the pro-B-cell stage.

TLS Online TPP Program

#Id: 1688

#Unit 4. Cell Communication and Cell Signaling

VpreB and λ5 (called a surrogate light chain), to form a pre-B-cell receptor.

TLS Online TPP Program

#Id: 1689

#Unit 4. Cell Communication and Cell Signaling

Light-chain recombination occurs at the small pre-B-cell stage of B-cell development.