The genomes of all retroviruses contain the three genes gag, pol and env.

For sustainable expression of a trangene in the successive generation of a cell line in culture, the ideal gene transfer can be obtained using 

 lentiviral vector 

adenoviral vector 

 plasmid DNA containing the transgene 

only transgenic DNA

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#Unit 8. Inheritance Biology

Chromosome deletion 

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#Unit 8. Inheritance Biology

Chromosome deletion - Loss of a chromosome segment.

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#Unit 8. Inheritance Biology

Deletion include,
Terminal deletion

ntercalary/interstitial deletion 

Microdeletion

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#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm

Wolf– Hirschhorn syndrome- Deletion on 4, short arm

Williams– Beuren syndrome - Deletion on 7, long arm

Prader– Willi syndrome- Deletion on 15 long arm 

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#Unit 8. Inheritance Biology

Deletion of a number of pairs that is not evenly divisible by three will lead to a frameshift mutation. 

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#Unit 8. Inheritance Biology

In an individual heterozygous for a deletion, the normal chromosome loops out during chromosome pairing in prophase I.