X-Linked Recessive Traits 

X-linked recessive traits appear more often in males than in females and are not passed from father to son.

Example – Hypophosphatemia , Rett syndrome

TLS Online TPP Program

#Id: 10510

#Unit 4. Cell Communication and Cell Signaling

The principal caspase in C. elegans is CED-3

TLS Online TPP Program

#Id: 10511

#Unit 4. Cell Communication and Cell Signaling

CED-3 in C. elegans = Caspase-9 in mammals

TLS Online TPP Program

#Id: 10512

#Unit 4. Cell Communication and Cell Signaling

EGL-1 protein binds to CED-9, alters its conformation, and catalyzes the release of CED-4 from CED-9

TLS Online TPP Program

#Id: 10513

#Unit 4. Cell Communication and Cell Signaling

Four freed CED-4 dimers combine to form a CED-4 octamer, which binds two molecules of the CED-3 zymogen (an enzymatically inactive precursor) triggers the formation of the active CED-3 protease

TLS Online TPP Program

#Id: 10514

#Unit 4. Cell Communication and Cell Signaling

In mammals

XIAP (inhibitor of apoptosis proteins) restrain both initiator and effector caspases

TLS Online TPP Program

#Id: 10515

#Unit 4. Cell Communication and Cell Signaling

XIAP has N-terminal BIR domains: 

BIR2 - binds to and inhibits caspase-3 and caspase-7

BIR3 - binds to and inhibits initiator caspase-9