Molecular genetic techniques are used to make a cDNA encoding a recombinant protein to which is fused a short sequence of amino acids called an epitope tagging.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Pyroptosis A form of regulated programmed cell death associated with inflammation, and often associated with infection with intracellular pathogens. Mediated by inflammasome-activated caspase-1.

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#Unit 4. Cell Communication and Cell Signaling

NOD1 also provides protection against the intracellular protozoan parasite Trypanosoma  cruzi,

NOD2 activates responses to some viruses, including influenza.

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#Unit 4. Cell Communication and Cell Signaling

The AIM2-like receptors (ALRs) are cytosolic receptors that bind DNA molecules from bacteria and viruses.

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#Unit 4. Cell Communication and Cell Signaling

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#Unit 4. Cell Communication and Cell Signaling

Inflammation

Tissue response to infection or damage which serves to eliminate

Classic signs of acute inflammation are heat (calore), pain (dolore), redness (rubor), swelling (tumor), and loss of function (functio laesa).

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#Unit 4. Cell Communication and Cell Signaling

Inflammatory response

The response includes both localized and systemic effects, consisting of altered patterns of blood flow, an influx of phagocytic and other immune cells, removal of foreign antigens, and healing of the damaged tissue.