A regulatory site that binds more negative regulators than positive regulators to control transcription is called a silencer.

TLS Online TPP Program

#Id: 2972

#Unit 3. Fundamental Processes

In yeast, Cdc6 is rapidly degraded during S phase, and as a result it is not available to support reloading of MCM proteins. Thus, the origin crumot be used for a second cycle of initiation during S phase.

TLS Online TPP Program

#Id: 1859

#Unit 3. Fundamental Processes

Sp1 (Mr  80,000) is a transcription activator for a large number of genes in higher eukaryotes. Its DNA binding site, the GC box consensus sequence GGGCGG.

TLS Online TPP Program

#Id: 4716

#Unit 13. Methods in Biology

Proteins that contain prosthetic groups (e.g. haem, flavin, carotenoid) and some metal–protein complexes, may have strong absorption bands in the UV/Vis range.

TLS Online TPP Program

#Id: 6118

#Unit 3. Fundamental Processes

The hMutb complex, a Msh2-Msh3 dimer, binds mismatched insertion/deletion/slippage loops, while the Msh2-Msh6 (hMuta) complex binds to single-base mismatches.

TLS Online TPP Program

#Id: 9635

#Unit 4. Cell Communication and Cell Signaling

Constitutively active Ras proteins (RasD) 

Replacement of the normal glycine 12 with any other amino acid (except proline) blocks the functional binding of GAP proteins and in essence “locks” Ras in the active GTP-bound state.