The influx of Ca2+ ions raises, triggering the fusion of insulin- containing secretory vesicles with the plasma membrane and the secretion of insulin

TLS Online TPP Program

#Id: 7463

#Unit 5. Developmental Biology

TLS Online TPP Program

#Id: 7464

#Unit 5. Developmental Biology

In prespore cells, PKA activation occurs by signalling cascade that is activated by SDF-3, which triggers the synthesis of GABA

TLS Online TPP Program

#Id: 7465

#Unit 5. Developmental Biology

Secreted GABA then acts on prestalk cells to induce the cell-surface exposure of the serine protease domain of the ABC transporter TagC.

TLS Online TPP Program

#Id: 7466

#Unit 5. Developmental Biology

GABA acts on prespore cells to induce secretion of AcbA.

TLS Online TPP Program

#Id: 7467

#Unit 5. Developmental Biology

AcbA is cleaved by the TagC protease to produce the peptide SDF-2.

TLS Online TPP Program

#Id: 7468

#Unit 5. Developmental Biology

SDF-2 activates the histidine phosphatase activity of DhkA, which induces spore encapsulation.