In GSV, much of the GLUT4 is tethered to the Golgi matrix, a network of coiled-coil proteins surrounding the Golgi complex,  by a TUG protein

TLS Online TPP Program

#Id: 6919

#Unit 8. Inheritance Biology

Chromosome deletion - Loss of a chromosome segment.

TLS Online TPP Program

#Id: 6920

#Unit 8. Inheritance Biology

Deletion include,
Terminal deletion

ntercalary/interstitial deletion 

Microdeletion

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#Id: 6921

#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm

Wolf– Hirschhorn syndrome- Deletion on 4, short arm

Williams– Beuren syndrome - Deletion on 7, long arm

Prader– Willi syndrome- Deletion on 15 long arm 

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#Id: 6922

#Unit 8. Inheritance Biology

Deletion of a number of pairs that is not evenly divisible by three will lead to a frameshift mutation. 

TLS Online TPP Program

#Id: 6923

#Unit 8. Inheritance Biology

In an individual heterozygous for a deletion, the normal chromosome loops out during chromosome pairing in prophase I.

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#Id: 6924

#Unit 8. Inheritance Biology

Deletion includes the centromere, then the chromosome will not segregate in meiosis or mitosis and will usually be lost.