Type 2 diabetes (non-insulin-dependent diabetes mellitus) is characterized by the dysregulation of insulin release from the B cells, along with insulin resistance in peripheral tissues such as skeletal muscle, brain, and liver

TLS Online TPP Program

#Id: 2388

#Unit 3. Fundamental Processes

Specific exonic and intronic sequences can enhance or suppress splice site selection.

TLS Online TPP Program

#Id: 2389

#Unit 3. Fundamental Processes

In general, SR proteins bind to exonic splicing enhancers and the hnRNP proteins bind to exonic silencers

TLS Online TPP Program

#Id: 2390

#Unit 3. Fundamental Processes

Binding of SR proteins to ESEs promotes or stabilizes U1 binding to the 5’ splice site and U2AF binding to the 3’ splice site.

TLS Online TPP Program

#Id: 2391

#Unit 3. Fundamental Processes

The Nova and Fox families of RNA-binding proteins can promote or suppress splice site selection in a context-dependent fashion.

TLS Online TPP Program

#Id: 2392

#Unit 3. Fundamental Processes

Trans-splicing is rare in multicellular eukaryotes, it occurs as the primary mechanism to process precursor RNA into mature, translatable mRNAs in some organisms, such as trypanosomes and nematodes.

TLS Online TPP Program

#Id: 2393

#Unit 3. Fundamental Processes

The SL RNA provides an exon that is connected to the first exon of an mRNA by trans-splicing. The reaction involves the same interactions as nuclear cis splicing but generates a Y-shaped RNA instead of a lariat.