In A cells, preproglucagon is processed primarily to glucagon and major proglucagon fragment (MPGF)

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#Id: 6569

#Unit 7. System Physiology – Animal

Glucagon secretion is increased by stimulation of the sympathetic nerves to the pancreas, & sympathetic effect is mediated via β-adrenergic receptors and cAMP

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#Unit 7. System Physiology – Animal

Somatostatin 14 and its amino terminal-extended form somatostatin 28 are found in the D cells of pancreatic islets

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#Id: 6571

#Unit 7. System Physiology – Animal

SS14 & SS28 both inhibits the secretion of insulin, glucagon, and pancreatic polypeptide and act locally within the pancreatic islets in a paracrine fashion

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#Id: 6572

#Unit 7. System Physiology – Animal

Human pancreatic polypeptide contains 36 amino acid residues and is produced by F cells in the islets

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#Id: 6573

#Unit 7. System Physiology – Animal

Pancreatic polypeptide is closely related to, 

polypeptide YY, a gastrointestinal peptide

neuropeptide Y, found in the brain & autonomic nervous system

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#Id: 6574

#Unit 7. System Physiology – Animal

In the normal male fetus,  the wolffian duct system on each side develops into the epididymis and vas deferens