Tight junctions between adjacent Sertoli cells near the basal lamina form a blood–testis barrier

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#Id: 10049

#Unit 4. Cell Communication and Cell Signaling

ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)

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#Id: 10050

#Unit 4. Cell Communication and Cell Signaling

Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell

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#Unit 4. Cell Communication and Cell Signaling

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

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#Id: 10052

#Unit 4. Cell Communication and Cell Signaling

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase

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#Id: 10053

#Unit 4. Cell Communication and Cell Signaling

γ-secretase complex contains 

Presenilin 1 (actual protease), aph-1, pen-2, & nicastrin

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#Id: 10054

#Unit 4. Cell Communication and Cell Signaling

Cleavage by the γ-secretase complex releases the Notch cytosolic segment, which translocates to the nucleus, interacts with a single DNA-binding transcription factor, CSL.